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KMID : 1094020140310020077
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Journal of Veterinary Clinics
2014 Volume.31 No. 2 p.77 ~ p.84
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A Study of Peripheral Blood and Bone Marrow Responses Depends on the Frequency of rhG-CSF Administration in Dogs
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Kim Ji-Hyun
Jee Cho-Hee
Won Jin-Hee
Jung Hae-Won
Moon Jong-Hyun
Cho Kyu-Woan
Jung Dong-In
Kang Byeong-Teck
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Abstract
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The present study evaluated that responses of peripheral and bone marrow depends on the frequency ofrecombinant human granulocyte colony-stimulating factor (rhG-CSF) administration in dogs. The rhG-CSF has beenrevealed that have a beneficial effect for dogs with myelosuppression secondary to chemotherapy or radiation but therewere no studies about the frequency of administration in dogs. In this research, rhG-CSF was administrated 5 μg/kg subcutaneously for each two-dogs group as follows: (1) every day for trial, (2) every other day for trial, (3) everythird day for trial. The peripheral blood analysis including direct microscopic differential counts of one hundred cellswas performed every day. Bone marrow aspiration was performed before administration of rh G-CSF, on the day of0, 3, 9 and when the WBC counts were decreased within the normal range (day 12 or 13). Rh G-CSF was welltoleratedand showed no side effects in all dogs. According to the present study, 5 μg/kg administration of rhG-CSFhave cell-specific, frequency-related effect on bone marrow and peripheral blood. Furthermore, the effects of rhG-CSFadministration on bone marrow sustained during the study and prolonged at least 3 days after discontinuing of rhGCSF treatment.
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KEYWORD
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rhG-CSF, dog, leukopenia
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